Ph.D. in Neuroscience, Tufts University Sackler School of Biomedical Sciences, Boston, MA (2018)
Role of Astrocyte-to-Neuron Communication in Circadian Behavior
Adviser: F Rob Jackson
Bachelor of Arts in Neuroscience, Smith College (2009)
Postdoctoral Researcher, Tufts University Sackler School of Biomedical Sciences, Boston, MA (Mar 2018 – Present)
Analysis of cycling astrocyte genes and characterization of NKT in the role of sleep and circadian behaviors.
Advisor: F Rob Jackson
Ph.D. Student, Tufts University Sackler School of Biomedical Sciences, Boston, MA (June 2012 – Mar 2018)
Identified glial factors important for circadian behavior through 1) identification of glial miRNAs and their mRNA targets required for normal circadian behavior and 2) isolation of cycling glial RNAs.
Advisor: F Rob Jackson
Research Technician, Tufts School of Dental Medicine, Boston, MA (Oct 2009 – Aug 2011)
Studied the effects of Sjögren’s Syndrome on tear production using a mouse model. Characterized adult stem cells involved in lacrimal gland repair using immunostaining, biochemistry and cell culture techniques. Work resulted in 3 first author papers. Aided research projects of multiple undergraduate and graduate students.
Advisor: Driss Zoukhri
Special Studies Student, University of Massachusetts, Amherst, MA (Feb 2009 – May 2009)
Special studies project examining the co-localization of vasopressin and GABA in the lateral septum of mice using immunocytochemistry. Contributed to processing and staining of brains in other projects resulting in an authorship opportunity.
Advisor: Benjamin Rood (De Vries Lab)
Summer Intern, Protein Biochemistry Lab, Biogen Idec, Cambridge, MA (May – Aug 2007, 2008)
Helped purify and characterize a TNF ligand family member. Developed a standard operating procedure for purifying a TNF ligand-Fc fusion protein. Developed an ELISA assay to assess the sensitivity of a number of assay kits. Archived a large collection of protein reagents and drug candidates for implementation into a new organization system.
Advisors: Dr. Yen-Ming Hsu, Dr. Lihe Su
Intern/Consultant, Lyftly, San Francisco Bay Area, CA (Jun 2018 – Aug 2018)
Researched industry training practices and worked on recruitment efforts.
Contract Editor, American Journal Experts, Durham, NC (May 2018 – Aug 2018)
Scientist, Emerson Science Communication Collaborative (Jan 2016 – Apr 2016)
The Science Communication Collaborative (SCC) connects early career scientific researchers with undergraduate students at Emerson College for training focused on science communication. I worked with undergraduate students to develop different methods of telling scientific stories.
Instructor, TUSM-UMASS Boston-Pathway to PhD Program (January 2015)
This program is designed to introduce undergraduates from UMASS-Boston to the life of a PhD student. I taught the first week in a three-week laboratory boot camp. Students were trained in basic laboratory techniques and guided through diverse experiments.
Sengupta S, Crowe LB, You S, Roberts MA, Jackson FR. A Secreted Ig-Domain Protein Required in Both Astrocytes and Neurons for Regulation of Drosophila Night Sleep. Current Biology 2019: 29: 2547-2554.
You S, Fulga TA, Van Vactor D, Jackson FR. Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila. Genetics 2018: 208(3):1195-1207.
Ng FS, Sengupta S, Huang Y, Yu AM, You S, Roberts MA, Iyer LK, Yang Y, Jackson FR. TRAP-seq profiling and RNAi-based genetic screens identify conserved glial genes required for adult Drosophila behavior. Front. Mol. Neurosci. 2016: 9:146.
Jackson FR, Ng FS, Sengupta S, You S, Huang Y. Glial cell regulation of rhythmic behavior. Methods in Enzymology 2015;552:45-73.
Rood BD, Stott R, You S, Smith C, Woodbury M, de Vries GJ. Site of origin of and sex differences in the vasopressin innervation of the mouse (Mus musculus) brain. J. Comp. Neurol. 2013: 521(10):2321-2358.
You S, Tariq A, Kublin C, Zoukhri D. Detection of BrdU-label retaining cells in the lacrimal gland: implications for tissue repair. Cell Tissue Res. 2012: 346(3):317-326.
You S, Avidan O, Tariq A, Ahluwalia I, Stark PC, Kublin C, Zoukhri D. Role of epithelial-mesenchymal transition in repair of the lacrimal gland following experimentally induced injury. Invest. Ophthalmol. Vis. Sci.2012:53:136-135.
You S, Kublin C, Avidan O, Miyasaki D, Zoukhri D. Isolation and propagation of mesenchymal stem cells from the lacrimal gland. Invest. Ophthalmol. Vis. Sci. 2011:52:2087-2094. (Cover Image)